My current setup consists of a very simple base layer, numbers layer, mouse layer and emoji layer. Still many options, but time will tell if changes are needed.
#define SP_MSE LT(_MOUSE, KC_SPC)
BASE layer
{ KC_GESC , KC_Q , KC_W , KC_E , KC_R , KC_T , KC_Y , KC_U , KC_I , KC_O , KC_P , KC_BSPC },
{ KC_TAB , KC_A , KC_S , KC_D , KC_F , KC_G , KC_H , KC_J , KC_K , KC_L , KC_SCLN , KC_ENT },
{ KC_LSFT , KC_Z , KC_X , KC_C , KC_V , KC_B , KC_N , KC_M , KC_COMM , KC_DOT , KC_SLSH , KC_QUOT },
{ KC_LCTL , KC_GRV , KC_LALT , KC_LGUI , MO(1) , SP_MSE , SP_MSE , KC_LEFT , KC_DOWN , KC_UP , KC_RGHT , MO(2) },
LOWER layer
{ _______ , KC_1 , KC_2 , KC_3 , KC_4 , KC_5 , KC_6 , KC_7 , KC_8 , KC_9 , KC_0 , KC_DEL },
{ _______ , KC_F1 , KC_F2 , KC_F3 , KC_LBRC , KC_MINS , KC_EQL , KC_RBRC , KC_F7 , KC_F8 , KC_F9 , _______ },
{ _______ , KC_F4 , KC_F5 , KC_F6 , KC_HOME , KC_BSLS , KC_MPLY , KC_END , KC_F10 , KC_F11 , KC_F12 , _______ },
{ _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ },
EMOJI layer
{ _______ , X(CLAP) , X(CUM) , X(BNIS) , X(BUTT) , X(CAR) , X(FIRE) , X(REDB) , X(MONY) , X(HNDR) , X(SOS) , _______ },
{ _______ , X(CELE) , X(PRAY) , X(NAIL) , X(OK) , X(THNK) , X(UNAM) , X(HEYE) , X(COOL) , X(EYES) , X(SMIR) , _______ },
{ _______ , X(TRIU) , X(SCRM) , X(VOMI) , X(DTIV) , X(EXPL) , X(HAIR) , X(DANC) , X(STRN) , X(LEFT) , X(RGHT) , _______ },
{ _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ },
MOUSE layer
{ _______ , KC_WH_L , KC_BTN1 , KC_MS_U , KC_BTN2 , KC_WH_U , KC_WH_U , KC_BTN1 , KC_MS_U , KC_BTN2 , KC_WH_L , _______ },
{ _______ , KC_WH_R , KC_MS_L , KC_MS_D , KC_MS_R , KC_WH_D , KC_WH_D , KC_MS_L , KC_MS_D , KC_MS_R , KC_WH_R , _______ },
{ _______ , KC_VOLD , KC_VOLU , KC_MPRV , KC_MNXT , KC_MPLY , KC_MPLY , KC_MPRV , KC_MNXT , KC_VOLD , KC_VOLU , _______ },
{ _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ , _______ },